| Title | A newly identified bocavirus species in human stool. |
| Publication Type | Journal Article |
| Year of Publication | 2009 |
| Authors | Kapoor, A, Slikas, B, Simmonds, P, Chieochansin, T, Naeem, A, Shaukat, S, Alam, MMasroor, Sharif, S, Angez, M, Zaidi, S, Delwart, E |
| Journal | The Journal of Infectious Diseases |
| Volume | 199 |
| Issue | 2 |
| Pagination | 196-200 |
| Date Published | 2009 Jan 15 |
| Keywords | Species Specificity |
| Abstract | Viral metagenomic analysis was used to identify a previously uncharacterized parvovirus species, "HBoV2," whose closest phylogenetic relative is the human bocavirus (HBoV). HBoV2 has a genomic organization identical to that of HBoV but has only 78%, 67%, and 80% identity, respectively, with the latter's NS1, NP1, and VP1/VP2 proteins. The study used polymerase chain reaction to detect HBoV2 sequences in 5 of 98 stool samples from Pakistani children and in 3 of 699 stool samples from Edinburgh. Nearly-full-length genome sequencing revealed the presence of 3 HBoV2 genotypes and evidence of recombination between genotypes. Further studies are necessary to identify anatomical sites of HBoV2 replication and potential associations with clinical symptoms or disease. |
